Details of the Target

General Information of Target

Target ID LDTP16886
Target Name Putative male-specific lethal-3 protein-like 2 (MSL3P1)
Gene Name MSL3P1
Synonyms
MSL3L2; Putative male-specific lethal-3 protein-like 2; MSL3-like 2; Male-specific lethal-3 homolog 2; Male-specific lethal-3 homolog pseudogene 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTMETLPKVLEVDEKSPEAKDLLPSQTASSLCISSRSESVWTTTPRSNWEIYRKPIVIMS
VGGAILLFGVVITCLAYTLKLSDKSLSILKMVGPGFLSLGLMMLVCGLVWVPIIKKKQKH
RQKSNFLRSLKSFFLTR
Target Bioclass
Other
Subcellular location
Nucleus
Function May be involved in chromatin remodeling and transcriptional regulation.
Uniprot ID
P0C860
HGNC ID
HGNC:17837

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C283(1.07)  LDD3427  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0164  [2]
NAIA_5
 Probe Info  		N.A.  LDD2224  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 CAL-148 C283(1.67)  LDD2285  [1]
 LDCM0023  KB03 FU-OV-1 C283(0.93)  LDD2745  [1]
 LDCM0024  KB05 SK-MEL-28 C283(1.07)  LDD3427  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264