Details of the Target

General Information of Target

Target ID LDTP16868
Target Name GATA-type zinc finger protein 1 (ZGLP1)
Gene Name ZGLP1
Gene ID 100125288
Synonyms
GLP1; GATA-type zinc finger protein 1; GATA-like protein 1; GLP-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGIPGLEGLHTWISIPFSFMYIVAVAGNIFLIFLIMTERSLHEPMYLFLSMLASADFLLA
TAAAPKVLAILWFHSMDISFGSCVSQMFFIHFIFVAESAILLAMAFDRYVAICYPLRYTI
LTSSAVRKIGIAAVVRSFFICCPFIFLVYRLTYCGRNIIPHSYCEHIARLACGNINVNII
YGLTVALLSTGLDIVLIIISYTMILHSVFQISSWAARFKALSTCGSHICVIFMFYTPAFF
SFLAHRFGGKTIPHHIHILVGSLYVLVPPMLNPIIYGVKTKQIKDRVILLFSPISVCC
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Transcriptional regulator that plays a key role in germ cell development. Determines the oogenic fate by activating key genes for the oogenic program and meiotic prophase entry. Acts downstream of bone morphogenetic protein (BMP) by regulating expression of genes required for the oogenic programs, which are repressed by Polycomb activities in sexually uncommitted germ cells. Regulates expression of STRA8, a central downstream effector for the meiotic program. Acts independently of retinoic acid (RA). In males, not required for germ-cell sex determination, but required to allow the spermatogonia to efficiently accomplish the meiotic prophase.
Uniprot ID
P0C6A0
Ensemble ID
ENST00000403903.7
HGNC ID
HGNC:37245

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0166  [1]

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060