Details of the Target

General Information of Target

Target ID LDTP16860
Target Name Putative protein N-methyltransferase FAM86B2 (FAM86B2)
Gene Name FAM86B2
Gene ID 653333
Synonyms
Putative protein N-methyltransferase FAM86B2; EC 2.1.1.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MISSVKLNLILVLSLSTMHVFWCYPVPSSKVSGKSDYFLILLNSCPTRLDRSKELAFLKP
ILEKMFVKRSFRNGVGTGMKKTSFQRAKS
Target Bioclass
Enzyme
Family
Class I-like SAM-binding methyltransferase superfamily, EEF2KMT family
Uniprot ID
P0C5J1
Ensemble ID
ENST00000262365.9
HGNC ID
HGNC:32222

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C72(1.92)  LDD0080  [1]
IPM
 Probe Info  		C290(0.00); C72(0.00)  LDD2156  [2]
NAIA_5
 Probe Info  		N.A.  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HCT 116 C72(1.92)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C72(1.71)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C72(1.72)  LDD0082  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264