Details of the Target

General Information of Target

Target ID LDTP16853
Target Name Protein phosphatase 1 regulatory subunit 17 (PPP1R17)
Gene Name PPP1R17
Gene ID 10842
Synonyms
C7orf16; GSBS; Protein phosphatase 1 regulatory subunit 17; G-substrate
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKLSVCLLLVTLALCCYQANAEFCPALVSELLDFFFISEPLFKLSLAKFDAPPEAVAAKL
GVKRCTDQMSLQKRSLIAEVLVKILKKCSV
Target Bioclass
Other
Function Inhibits phosphatase activities of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) complexes.
Uniprot ID
O96001
Ensemble ID
ENST00000342032.8
HGNC ID
HGNC:16973

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.R88I .
KMCH1 SNV: p.K36R .
MOLT4 Deletion: p.N49MfsTer6 .
TCCSUP SNV: p.H105Y .
TE1 SNV: p.V56A .
TF1 SNV: p.V50E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C839(0.00); C108(0.00); C118(0.00); C426(0.00)  LDD0161  [1]

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060