General Information of Target

Target ID LDTP16852
Target Name Secretoglobin family 1D member 2 (SCGB1D2)
Gene Name SCGB1D2
Gene ID 10647
Synonyms
LIPHB; LPNB; Secretoglobin family 1D member 2; Lipophilin-B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVCGGFACSKNCLCALNLLYTLVSLLLIGIAAWGIGFGLISSLRVVGVVIAVGIFLFLIA
LVGLIGAVKHHQVLLFFYMIILLLVFIVQFSVSCACLALNQEQQGQLLEVGWNNTASARN
DIQRNLNCCGFRSVNPNDTCLASCVKSDHSCSPCAPIIGEYAGEVLRFVGGIGLFFSFTE
ILGVWLTYRYRNQKDPRANPSAFL
Target Type
Literature-reported
Target Bioclass
Other
Family
Secretoglobin family, Lipophilin subfamily
Subcellular location
Secreted
Function May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.
TTD ID
T46824
Uniprot ID
O95969
DrugMap ID
TT5D314
Ensemble ID
ENST00000244926.4
HGNC ID
HGNC:18396

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C65(2.61)  LDD2268  [1]
IA-alkyne
 Probe Info 
N.A.  LDD0161  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 BRX211 C65(2.61)  LDD2268  [1]
 LDCM0023  KB03 BRX211 C65(3.14)  LDD2685  [1]
 LDCM0024  KB05 BRX211 C65(4.09)  LDD3102  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060