Details of the Target

General Information of Target

Target ID LDTP16829
Target Name Tetraspanin-9 (TSPAN9)
Gene Name TSPAN9
Gene ID 10867
Synonyms
NET5; Tetraspanin-9; Tspan-9; Tetraspan NET-5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFRGAWMWPGKDAAALTICCCCCCWAPRPSDKPCADSERAQRWRLSLASLLFFTVLLADH
LWLCAGARPRARELSSAMRPPWGAGRERQPVPPRAVLPLPPPPPGEPSAPPGTCGPRYSN
LTKAAPAAGSRPVCGGVPEPTGLDAACTKLQSLQRLFEPTTPAPPLRPPDSLSRAPAEFP
SAKKNLLKGHFRNFTLSFCDTYTVWDLLLGMDRPDSLDCSLDTLMGDLLAVVASPGSGAW
EACSNCIEAYQRLDRHAQEKYDEFDLVLHKYLQAEEYSIRSCTKGCKAVYKAWLCSEYFS
VTQQECQRWVPCKQYCLEVQTRCPFILPDNEEMVYGGLPGFICTGLLDTSPKRLETKCCD
VQWVSCEAKKKKFKESEAPKTHQQQFHHSYFHHYHQQYHHYHPHHDPPGRVSNKPALLPV
SGGSRLSPSRIRLCVLVLMLLHTVVSFSSNQGGGGLGLETLPALEEGLTREE
Target Bioclass
Transporter and channel
Family
Tetraspanin (TM4SF) family
Subcellular location
Membrane
Uniprot ID
O75954
Ensemble ID
ENST00000011898.10
HGNC ID
HGNC:21640

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C190(1.99)  LDD1700  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C190(1.00)  LDD2117  [1]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C190(1.07)  LDD2099  [1]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C190(1.53)  LDD2105  [1]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C190(0.98)  LDD2107  [1]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C190(0.95)  LDD2115  [1]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C190(0.90)  LDD2125  [1]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C190(1.13)  LDD2127  [1]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C190(0.75)  LDD2134  [1]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C190(1.04)  LDD2135  [1]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C190(0.99)  LDD2136  [1]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C190(1.26)  LDD2137  [1]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C190(1.99)  LDD1700  [1]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C190(0.84)  LDD2140  [1]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C190(0.71)  LDD2146  [1]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C190(0.92)  LDD2148  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761