General Information of Target

Target ID LDTP16828
Target Name NALCN channel auxiliary factor 2 (NALF2)
Gene Name NALF2
Gene ID 27112
Synonyms
FAM155B; TED; TMEM28; NALCN channel auxiliary factor 2; Protein TED; Transmembrane protein 28; Transmembrane protein FAM155B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASPSPPPESKGLLTFEDVAVFFTQEEWDYLDPAQRSLYKDVMMENYGNLVSLDVLNRDK
DEEPTVKQEIEEIEEEVEPQGVIVTRIKSEIDQDPMGRETFELVGRLDKQRGIFLWEIPR
ESLTQEQRMFRENTNIIRKRPNSEEKCHKCEECGKGFVRKAHFIQHQRVHTGEKPFQCNE
CGKSFSRSSFVIEHQRIHTGERPYECNYCGKTFSVSSTLIRHQRIHTGERPYQCNQCKQS
FSQRRSLVKHQRIHTGEKPHKCSDCGKAFSWKSHLIEHQRTHTGEKPYHCTKCKKSFSRN
SLLVEHQRIHTGERPHKCGECGKAFRLSTYLIQHQKIHTGEKPFLCIECGKSFSRSSFLI
EHQRIHTGERPYQCKECGKSFSQLCNLTRHQRIHTGDKPHKCEECGKAFSRSSGLIQHQR
IHTREKTYPYNETKESFDPNCSLVIQQEVYPKEKSYKCDECGKTFSVSAHLVQHQRIHTG
EKPYLCTVCGKSFSRSSFLIEHQRIHTGERPYLCRQCGKSFSQLCNLIRHQGVHTGNKPH
KCDECGKAFSRNSGLIQHQRIHTGEKPYKCEKCDKSFSQQRSLVNHQKIHAEVKTQETHE
CDACGEAFNCRISLIQHQKLHTAWMQ
Target Bioclass
Other
Family
NALF family
Subcellular location
Membrane
Function Probable component of the NALCN channel complex, a channel that regulates the resting membrane potential and controls neuronal excitability.
Uniprot ID
O75949
Ensemble ID
ENST00000252338.5
HGNC ID
HGNC:30701

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C67(1.70)  LDD3345  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A498 C67(1.78)  LDD2259  [1]
 LDCM0023  KB03 A498 C67(1.44)  LDD2676  [1]
 LDCM0024  KB05 NCI-H1650 C67(1.70)  LDD3345  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840