General Information of Target

Target ID LDTP16788
Target Name Protein phosphatase inhibitor 2 family member C (PPP1R2C)
Gene Name PPP1R2C
Synonyms
PPP1R2P9; Protein phosphatase inhibitor 2 family member C; PPP1R2 family member B; Protein phosphatase 1, regulatory subunit 2 pseudogene 9; Type-1 protein phosphatase inhibitor 4; I-4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSRRNCWICKMCRDESKRPPSNLTLEEVLQWAQSFENLMATKYGPVVYAAYLKMEHSDEN
IQFWMACETYKKIASRWSRISRAKKLYKIYIQPQSPREINIDSSTRETIIRNIQEPTETC
FEEAQKIVYMHMERDSYPRFLKSEMYQKLLKTMQSNNSF
Target Bioclass
Enzyme
Family
Protein phosphatase inhibitor 2 family
Function Functions as a protein phosphatase inhibitor. It inhibits activity of the catalytic subunit of PP1 and weakly inhibits the activity of myosin-associated phosphates.
Uniprot ID
O14990
Ensemble ID
ENST00000378131.4
HGNC ID
HGNC:16324

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info 
C65(0.00); C320(0.00); C157(0.00)  LDD0161  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) PPP phosphatase family P62136
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB) PPP phosphatase family P62140
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PPP1CC) PPP phosphatase family P36873

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060