General Information of Target

Target ID LDTP16771
Target Name Piercer of microtubule wall 2 protein (PIERCE2)
Gene Name PIERCE2
Gene ID 145788
Synonyms
C15orf65; Piercer of microtubule wall 2 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGCGPSQPAEDRRRVRAPKKGWKEEFKADVSVPHTGENCSPRMEAALTKNTVDIAEGLEQ
VQMGSLPGTISENSPSPSERNRRVNSDLVTNGLINKPQSLESRERQKSSDILEELIVQGI
IQSHSKVFRNGESYDVTLTTTEKPLRKPPSRLKKLKIKKQVKDFTMKDIEEKMEAAEERR
KTKEEEIRKRLRSDRLLPSANHSDSAELDGAEVAFAKGLQRVRSAGFEPSDLQGGKPLKR
KKSKCDATLIDRNESDESFGVVESDMSYNQADDIVY
Target Bioclass
Other
Family
PIERCE2 family
Subcellular location
Cytoplasm, cytoskeleton, cilium axoneme
Function Microtubule inner protein involved in the attachment of outer dynein arms (ODAs) to dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
Uniprot ID
H3BRN8
Ensemble ID
ENST00000569691.2
HGNC ID
HGNC:44654

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPIAA_L
 Probe Info 
N.A.  LDD0031  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcriptional regulator QRICH1 (QRICH1) . Q2TAL8

References

1 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647