Details of the Target

General Information of Target

Target ID LDTP16766
Target Name Alternative prion protein (PRNP)
Gene Name PRNP
Gene ID 5621
Synonyms
ALTPRP; PRIP; PRP; Alternative prion protein; AltPrP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVNSVVFFEITRDGKPLGRISIKLFADKIPKTAENFRALSTGEKGFRYKGSCFHRIIPGF
MCQGGDFTRPNGTGDKSIYGEKFDDENLIRKHTGSGILSMANAGPNTNGSQFFICAAKTE
WLDGKHVAFGKVKERVNIVEATEHFGYRNSKTSKKITIADCGQF
Target Bioclass
Other
Subcellular location
Mitochondrion outer membrane
Uniprot ID
F7VJQ1
HGNC ID
HGNC:9449

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C214(1.02)  LDD3312  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A101D C214(1.19)  LDD2250  [1]
 LDCM0023  KB03 A2058 C214(1.08)  LDD2670  [1]
 LDCM0024  KB05 HMCB C214(1.02)  LDD3312  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840