Details of the Target

General Information of Target

Target ID LDTP16734
Target Name Transmembrane protein 150C (TMEM150C)
Gene Name TMEM150C
Gene ID 441027
Synonyms
Transmembrane protein 150C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRPKTGQVGCETPEELGPGPRQRWPLLLLGLAMVAHGLLRPMVAPQSGDPDPGASVGSSR
SSLRSLWGRLLLQPSPQRADPRCWPRGFWSEPQSLCYVFGTGTKVTVLGQPKANPTVTLF
PPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYL
SLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS
Target Bioclass
Transporter and channel
Family
DRAM/TMEM150 family
Subcellular location
Cell membrane
Function Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception.
Uniprot ID
B9EJG8
Ensemble ID
ENST00000449862.7
HGNC ID
HGNC:37263

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 Deletion: p.N119IfsTer17 .
HCT15 SNV: p.E236Ter .
KARPAS299 SNV: p.E236G .
LNCaP clone FGC SNV: p.Q147Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		N.A.  LDD2223  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264