Details of the Target

General Information of Target

Target ID LDTP16701
Target Name Putative neutrophil cytosol factor 1C (NCF1C)
Gene Name NCF1C
Synonyms
SH3PXD1C; Putative neutrophil cytosol factor 1C; NCF-1C; Putative SH3 and PX domain-containing protein 1C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPWTILLFAAGSLAIPAPSIRLVPPYPSSQEDPIHIACMAPGNFPGANFTLYRGGQVVQL
LQAPTDQRGVTFNLSGGSSKAPGGPFHCQYGVLGELNQSQLSDLSEPVNVSFPVPTWILV
LSLSLAGALFLLAGLVAVALVVRKVKLRNLQKKRDRESCWAQINFDSTDMSFDNSLFTVS
AKTMPEEDPATLDDHSGTTATPSNSRTRKRPTSTSSSPETPEFSTFRACQ
Target Bioclass
Other
Subcellular location
Cytoplasm
Function May be required for activation of the latent NADPH oxidase (necessary for superoxide production).
Uniprot ID
A8MVU1
HGNC ID
HGNC:32523

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C98(1.61)  LDD3334  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HG-3 C98(1.47)  LDD2355  [1]
 LDCM0023  KB03 HG-3 C98(2.16)  LDD2772  [1]
 LDCM0024  KB05 MOLM-16 C98(1.61)  LDD3334  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840