Details of the Target

General Information of Target

Target ID LDTP16636
Target Name Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5 (AGAP5)
Gene Name AGAP5
Gene ID 729092
Synonyms
CTGLF2; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5; AGAP-5; Centaurin-gamma-like family member 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSVTGFTITDEKVHLYHSIEKEKTVRHIGDLCSSHSVKKIQVGICLLLVELCERFTFFEV
VCNMIPFCTIKLGYHNCQAAILNLCFIGTSILTPVFVRWLTDVYLGRNKLVYICLFLHFL
GTALLSVVAFPLEDFYLGTYHAVNNIPKTEQHRLFYVALLTICLGIGGVRAIVCPLGAFG
LQEYGSQKTMSFFNWFYWLMNLNATIVFLGISYIQHSQAWALVLLIPFMSMLMAVITLHM
IYYNLIYQSEKRCSLLTGVGVLVSALKTCHPQYCHLGRDVTSQLDHAKEKNGGCYSELHV
EDTTFFLTLLPLFIFQLLYRMCIMQIPSGYYLQTMNSNLNLDGFLLPIAVMNAISSLPLL
ILAPFLEYFSTCLFPSKRVGSFLSTCIIAGNLFAALSVMIAGFFEIHRKHFPAVEQPLSG
KVLTVSSMPCFYLILQYVLLGVAETLVNPALSVISYRFVPSNVRGTSMNFLTLFNGFGCF
TGALLVKLVYLISDGNWFPNTLNKGNLESFFFFLASLTLLNVLGFCSVSQRYCNLNHFNA
QNIRGSNLEETLLLHEKSLKFYGSIQEFSSSIDLWETAL
Target Bioclass
Other
Family
Centaurin gamma-like family
Function Putative GTPase-activating protein.
Uniprot ID
A6NIR3
Ensemble ID
ENST00000374094.9
HGNC ID
HGNC:23467

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD2241  [1]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [1]
NAIA_5
 Probe Info  		N.A.  LDD2223  [2]

References

1 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264