Details of the Target

General Information of Target

Target ID LDTP16606
Target Name WD repeat-containing protein 97 (WDR97)
Gene Name WDR97
Gene ID 340390
Synonyms
KIAA1875; WD repeat-containing protein 97
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWPFPSRSLFPPPTQAWLQTVSSDPEAQGWGAWNETKEILGPEGGEGKEEKEEEEDAEED
QDGDAGFLLSLLEQENLAECPLPDQELEAIKMKVCAMEQAEGTPRPPGVQQQAEEEEGTA
AGQLLSPETVGCPLSGTPEEKVEADHRSVYVGNVDYGGSAEELEAHFSRCGEVHRVTILC
DKFSGHPKGYAYIEFATKGSVQAAVELDQSLFRGRVIKVLPKRTNFPGISSTDRGGLRGH
PGSRGAPFPHSGLQGRPRLRPQGQNRARGKFSPWFSPY
Target Bioclass
Other
Uniprot ID
A6NE52
Ensemble ID
ENST00000323662.9
HGNC ID
HGNC:26959

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DOTC24510 SNV: p.S1439P .
G402 Substitution: p.R1559S .
HCT116 Deletion: p.E1098RfsTer23 .
HEC1 SNV: p.R1434H .
HEC1B SNV: p.R1434H .
JHH4 SNV: p.D1224H .
KU1919 SNV: p.S1196N; p.S1427R .
LOXIMVI SNV: p.S1369F .
MDAMB231 SNV: p.S1474L .
MEWO SNV: p.A1068D; p.P1076T .
NUGC3 SNV: p.E1098G .
RKO Deletion: p.E1098RfsTer23 .
SUPT1 Substitution: p.L1435A .
SW1271 SNV: p.E1111Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0223  [1]
DBIA
 Probe Info  		C560(2.38)  LDD2236  [2]
IPM
 Probe Info  		N.A.  LDD0147  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0223  [1]

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 Global profiling of phosphorylation-dependent changes in cysteine reactivity. Nat Methods. 2022 Mar;19(3):341-352. doi: 10.1038/s41592-022-01398-2. Epub 2022 Feb 28.
Mass spectrometry data entry: PXD026730
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255