Details of the Target

General Information of Target

Target ID LDTP16599
Target Name Putative tripartite motif-containing protein 49B (TRIM49B)
Gene Name TRIM49B
Gene ID 283116
Synonyms
RNF18B; Putative tripartite motif-containing protein 49B; RING finger protein 18B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEEENATLLTEFVLTGFLYQPQWKIPLFLAFLVIYLITIMGNLGLIAVIWKDPHLHIPMY
LLLGNLAFVDAWISSTVTPKMLNNFLAKSKMISLSECKIQFFSIAIGVTTECFLLATMAY
DRYVAICKPLLYPAIMTNGLCIRLLILSYIAGILHALIHEGFLFRLTFCNSNIVHHIYCD
TIPLSKISCTDSSINFLMVFIFSGSIQVFSIVTILISYTFVLFTVLEKKSDKGVRKAFST
CGAHLFSVCLYYGPLLLMYVGPASPQADGQNMVEPLFYTVIIPLLNPIIYSLRNKQVIVS
FIKMLKRNVKVSY
Target Bioclass
Enzyme
Family
TRIM/RBCC family
Uniprot ID
A6NDI0
Ensemble ID
ENST00000332682.9
HGNC ID
HGNC:42955

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C152(2.66)  LDD3434  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 SK-N-MC C152(2.08)  LDD2600  [1]
 LDCM0023  KB03 SK-N-MC C152(2.27)  LDD3017  [1]
 LDCM0024  KB05 SK-N-MC C152(2.66)  LDD3434  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840