Details of the Target

General Information of Target

Target ID LDTP16545
Target Name Fer-1-like protein 5 (FER1L5)
Gene Name FER1L5
Gene ID 90342
Synonyms
Fer-1-like protein 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTPALREATAKGISFSSLPSTMESDKMLYMESPRTVDEKLKGDTFSQMLGFPTPEPTLNT
NFVNLKHFGSPQSSKHYQTVFLMRSNSTLNKHNENYKQKKLGEPSCNKLKNILYNGSNIQ
LSKICLSHSEEFIKKEPLSDTTSQCMKDVQIILDSNITKDTNVDKVQLQNCKWYQENALL
DKVTDAEIKKGLLHCTQKKIVPGHSNVPVSSSAAEKEEEVHARLLHCVSKQKILLSQARR
TQKHLQMLLAKHVVKHYGQQMKLSMKHQLPKMKTFHEPTTILGNSLPKCTEIKPEVNTLT
AENKLWDDAKNGFARCTAAEIQRFAFSATGLLSHVEEGLDSDATDSSSDDDLDEYTLRKN
VAVNCSTEWKWLVDRARVGSRWTWLQAQISDLECKIQQLTDIHRQIRASKGIVVLEECQL
PKDILKKQMQFADQAASLNILGNPQVPQECQDPVPEQDFEMSPSSPTLLLRNIEKQSAQL
TEIINSLIAPLNLSPTSSPLSSKSCSHKCLANGIYRSASENLDELSSSSSWLLNQKHSKK
KRKDRTRLKSSSLTFMSTSARTRPLQSFHKRKLYRLSPTFYWTPQTLPSKETAFLNTTQM
PCLQSASTWSSYEHNSESYLLREHVSELDSSFHSVLSLPSDVPLHFHFETLLKKTEIKGN
LAENKFVDEYIISPSPVHSTLNQWRNGYSPICKPQIRSESSAQLLQGRKKRHLSETALGE
RTKLEESDFQHTESGSHSNFTAVSNVNVLSRIQNSSRNTARRRLRSESSYDIDNIVIPMS
LVAPAKLEKLQYKEILTPSWRMVVLQPLDEYNLGKEEIEDLSDEVFSLRHKKYEEREQAR
WSLWEQSKWHRRNSRAYSKNVEGQDLLLKEYPNNFSSSQQCAAASPPGLPSENQDLCAYG
LPSLNQSQETKSLWWERRAFPLKGEDMAALLCQDEKKDQVERSSTAFHGEIFGTSVPENG
HHPKKQSDGMEEYKTFGLGLTNVKKNR
Target Bioclass
Other
Family
Ferlin family
Subcellular location
Cell membrane
Function Plays a role in myoblast fusion; probable mediator of endocytic recycling for membrane trafficking events during myotube formation.
Uniprot ID
A0AVI2
Ensemble ID
ENST00000624922.6
HGNC ID
HGNC:19044

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Insertion: p.C1002MfsTer71
SNV: p.C1002G;p.K1235T		 .
C32 SNV: p.L67F .
CHL1 SNV: p.A145G; p.G765C .
COLO800 SNV: p.L605Q .
HCC827 SNV: p.G246R .
IGROV1 Insertion: p.M1185HfsTer22 .
KMCH1 SNV: p.A869T .
KYSE510 SNV: p.H959Q; p.E960D .
MCC13 SNV: p.E1575K .
MCC26 SNV: p.G463D .
MFE319 SNV: p.K444N; p.P1648H .
MM1S SNV: p.W371L .
NCIH1975 SNV: p.E1417K .
NCIH2286 SNV: p.M23K; p.P88S .
NCIH446 SNV: p.S386N .
SNGM Deletion: p.N1062TfsTer33 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0036  [1]

References

1 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853