Details of the Target

General Information of Target

Target ID LDTP16543
Target Name Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5B (GNG5B)
Gene Name GNG5B
Synonyms
GNG5P2; Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLSLLLLLLGLGSVFSAVISQKPSRDICQRGTSLTIQCQVDSQVTMMFWYRQQPGQSLTL
IATANQGSEATYESGFVIDKFPISRPNLTFSTLTVSNMSPEDSSIYLCSVE
Target Bioclass
Other
Family
G protein gamma family
Subcellular location
Cell membrane
Function
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Uniprot ID
A0A804HLA8
Ensemble ID
ENST00000372054.3
HGNC ID
HGNC:24826

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		N.A.  LDD2223  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264