Details of the Target

General Information of Target

Target ID LDTP16524
Target Name Histone H2B type 2-K1 (H2BK1)
Gene Name H2BK1
Synonyms
H2BE1; Histone H2B type 2-K1; Histone H2B type 2-E1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAGVIRPLCDFQLPLLRHHPFLPSDPEPPETSEEEEEEEEEEEEEEGEGEGLGGCGRIL
PSSGRAEATEEAAPEGPGSPETPLQLLRFSELISDDIRRYFGRKDKGQDPDACDVYADSR
PPRSTARELYYADLVRLARGGSLEDEDTPEPRVPQGQVCRPGLSGDRAQPLGPLAELFDY
GLQQYWGSRAAAGWSLTLERKYGHITPMAQRKLPPSFWKEPTPSPLGLLHPGTPDFSDLL
ASWSTEACPELPGRGTPALEGARPAEA
Target Bioclass
Other
Family
Histone H2B family
Subcellular location
Chromosome
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Uniprot ID
A0A2R8Y619
Ensemble ID
ENST00000644661.2
HGNC ID
HGNC:53833

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		H106(0.00); K113(0.00)  LDD0227  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa H106(0.00); K113(0.00)  LDD0227  [1]

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.