Details of the Target

General Information of Target

Target ID LDTP16317
Target Name Protocadherin alpha-8 (PCDHA8)
Gene Name PCDHA8
Gene ID 56140
Synonyms
Protocadherin alpha-8; PCDH-alpha-8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKIQKKLTGCSRLMLLCLSLELLLEAGAGNIHYSVPEETDKGSFVGNIAKDLGLQPQELA
DGGVRIVSRGRMPLFALNPRSGSLITARRIDREELCAQSMPCLVSFNILVEDKMKLFPVE
VEIIDINDNTPQFQLEELEFKMNEITTPGTRVSLPFGQDLDVGMNSLQSYQLSSNPHFSL
DVQQGADGPQHPEMVLQSPLDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPP
AFTQAQYHINVPENVPLGTQLLMVNATDPDEGANGEVTYSFHNVDHRVAQIFRLDSYTGE
ISNKEPLDFEEYKMYSMEVQAQDGAGLMAKVKVLIKVLDVNDNAPEVTITSVTTAVPENF
PPGTIIALISVHDQDSGDNGYTTCFIPGNLPFKLEKLVDNYYRLVTERTLDRELISGYNI
TITAIDQGTPALSTETHISLLVTDINDNSPVFHQDSYSAYIPENNPRGASIFSVRAHDLD
SNENAQITYSLIEDTIQGAPLSAYLSINSDTGVLYALRSFDYEQFRDMQLKVMARDSGDP
PLSSNVSLSLFLLDQNDNAPEILYPALPTDGSTGVELAPLSAEPGYLVTKVVAVDRDSGQ
NAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTL
TVAVADRISDILADLGSLEPSAKPNDSDLTLYLVVAAAAVSCVFLAFVIVLLAHRLRRWH
KSRLLQASGGGLASMPGSHFVGVDGVRAFLQTYSHEVSLTADSRKSHLIFPQPNYADTLI
SQESCEKKGFLSAPQSLLEDKKEPFSQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNN
QFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSN
ATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
Target Bioclass
Other
Subcellular location
Cell membrane
Function Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Uniprot ID
Q9Y5H6
Ensemble ID
ENST00000378123.4
HGNC ID
HGNC:8674

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.V624M .
CAL148 SNV: p.R569W .
COLO800 Insertion: p.V499GfsTer33 .
EGI1 SNV: p.I251M .
HDQP1 Insertion: p.L413SfsTer14 .
HEC1 SNV: p.V374M; p.V464M; p.G515S .
HEC1B SNV: p.V374M; p.V464M; p.G515S .
HT1376 SNV: p.R151G .
JURKAT SNV: p.A205T; p.A587T; p.A596V .
KYSE30 SNV: p.R171T .
L428 SNV: p.P348S .
MCC13 SNV: p.S354F .
MCC26 SNV: p.S584F .
MEWO SNV: p.R415C; p.A454T .
MFE319 SNV: p.A22V .
NALM6 SNV: p.A427T .
NCIH1993 SNV: p.L721M .
NCIH2122 SNV: p.G156D .
NCIH23 SNV: p.A456E .
OVTOKO SNV: p.K736E .
TOV21G SNV: p.P778T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TFBX
 Probe Info  		N.A.  LDD0148  [1]

References

1 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255