Details of the Target

General Information of Target

Target ID LDTP16307
Target Name Protocadherin gamma-A8 (PCDHGA8)
Gene Name PCDHGA8
Gene ID 9708
Synonyms
KIAA0327; Protocadherin gamma-A8; PCDH-gamma-A8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAPTKCQLRGRLVLLCSLLGMLWEARASQIRYSVPEETEKGYIVGNISKDLALEPRELA
ERRVRIVSRGRTQLFSLNPRSGTLVTAGRIDREELCAQSPRCLVNFKVLVEDRVKLYGIE
IEVTDINDSAPKFQAESLEVKINEIAVPGARYPLPEAIDPDVGVNSLQSYQLSPNHHFSL
NVQTGDNGAINPELVLERALDREEATAHHLVLTASDGGEPRRSSTVRIHVTVLDTNDNAP
VFAQRIYRVKVLENVPPGTWLLTATASDLDEGINGKVAYKFWKINEKQSLLFQLNENTGE
ISTAKSLDYEECSFYEMEIQAEDGGGLKGWTKVLISVEDVNDNRPEVTITSLFSPVREDA
PQGTVILLFNAHDRDSGKNGQVVCSIQENLSFTLENSEEDYYRLLTAQILDREKASEYNI
TVTATDRGTPPLSTEIHITLQVTDINDNPPAFSQASYSVYLPENNARGTSIFSVIAYDPD
SNENSRVIYSLAEDTIQGSPLSTYVSINSDTGVLYALCSFDYEQFRDLQMQVTASDSGSP
PLSSNVSLRLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQ
NAWLSYRLFKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTL
TVAIADSIPDILADLGSLQIPADLEASDLTLYLVVAVAVVSCVFLTFVITLLALRLRHWH
SSHLLRATSDGLAGVPTSHFVGVDGVRAFLQTYSQEFSLTADSRKSHLIFPQPNYADTLI
SQQSCEKNEPLCVSVDSKFPIEDTPLVPQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPN
NQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGS
NATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
Target Bioclass
Other
Subcellular location
Cell membrane
Function Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Uniprot ID
Q9Y5G5
Ensemble ID
ENST00000398604.3
HGNC ID
HGNC:8706

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DOTC24510 SNV: p.V241L .
HCT116 SNV: p.R526Q .
HDQP1 SNV: p.R584S .
Ishikawa (Heraklio) 02 ER SNV: p.L172I .
JURLMK1 SNV: p.K332Q .
KYM1 SNV: p.G325A .
LNCaP clone FGC SNV: p.S481N .
MCC13 SNV: p.A60V; p.P290S .
MDAMB468 Deletion: p.Q772SfsTer21 .
NALM6 SNV: p.A18V .
NCIH1299 SNV: p.G428R .
NCIH1793 SNV: p.P345Q .
NCIH1993 SNV: p.V735L .
NCIH2286 SNV: p.F452L .
PF382 SNV: p.N464S .
RVH421 SNV: p.S360F .
SUPT1 SNV: p.A146T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C96(1.41)  LDD3323  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 SKMEL24 C96(1.75)  LDD2489  [1]
 LDCM0023  KB03 A101D C96(1.01)  LDD2890  [1]
 LDCM0024  KB05 SKMEL24 C96(1.41)  LDD3323  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840