Details of the Target

General Information of Target

Target ID LDTP16268
Target Name Small ribosomal subunit protein bS1m (MRPS28)
Gene Name MRPS28
Gene ID 28957
Synonyms
MRPS35; Small ribosomal subunit protein bS1m; 28S ribosomal protein S28, mitochondrial; MRP-S28; S28mt; 28S ribosomal protein S35, mitochondrial; MRP-S35; S35mt
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGPLTIRDVTVEFSLEEWHCLDTAQQNLYRDVMLENYRNLVFLGIAVSKPDLITCLEQGK
EPCNMKRHEMVAKPPVMCSHIAEDLCPERDIKYFFQKVILRRYDKCEHENLQLRKGCKSV
DECKVCKGGYNGLNQCLITTQSKMYQCDKYVKVFYKFSNSDRHKIRHTEKKTCKCKECGK
SFCMLSQLTRHKRIHIRENSHKCEECGKAFNQSSALTRHKMTHTGEKPYKCEECGKAFNR
SSHLTQHKVIHTREKPYKCEECGKAFNRSSHITQHKRIHNREKPFKYDECCKAFKWSSAL
TTLTQHKRIHTGEKPYKCEECGKAFNQSSALTRHKMIHTGEKPFQCEECGKAFNRSSHLT
QHKIIHTKEKPYKCEECGKAFNRSSHLTKHKRIHTREKAYKCDEYCKAFNWSSALTTLTQ
HKIIHTGEKPYKCEECGKAFNRSSYLIRHKIIHTGEKPYKCEECGKAFNQSSHLTQHKII
HTGEKPYKCEECGKAFNRSSHLSQHKIIHTGEKPYKCEECGKPFNRFSYLTVHKRIHAGE
NPNKYEECGKACNHSSNLTKHNS
Target Bioclass
Other
Family
Bacterial ribosomal protein bS1 family
Subcellular location
Mitochondrion
Uniprot ID
Q9Y2Q9
Ensemble ID
ENST00000276585.9
HGNC ID
HGNC:14513

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K136(9.51); K75(3.26)  LDD0277  [1]
BTD
 Probe Info  		C122(0.81)  LDD2092  [2]
ATP probe
 Probe Info  		K65(0.00); K181(0.00)  LDD0199  [3]
IA-alkyne
 Probe Info  		C122(0.00); C124(0.00)  LDD0165  [4]
IPM
 Probe Info  		N.A.  LDD0147  [5]
1c-yne
 Probe Info  		K75(0.00); K176(0.00)  LDD0228  [6]
Acrolein
 Probe Info  		N.A.  LDD0217  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C122(0.71)  LDD2112  [2]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C122(0.95)  LDD2152  [2]
 LDCM0108  Chloroacetamide HeLa H86(0.00); C122(0.00)  LDD0222  [7]
 LDCM0107  IAA HeLa H86(0.00); H59(0.00); C122(0.00); C124(0.00)  LDD0221  [7]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C122(0.79)  LDD2102  [2]
 LDCM0109  NEM HeLa H86(0.00); H59(0.00)  LDD0223  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C122(0.81)  LDD2092  [2]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C122(0.85)  LDD2093  [2]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C122(0.95)  LDD2094  [2]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C122(0.82)  LDD2098  [2]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C122(0.80)  LDD2104  [2]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C122(0.80)  LDD2108  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C122(0.68)  LDD2109  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C124(0.99); C122(1.21)  LDD2119  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C124(0.52)  LDD2123  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C122(0.59)  LDD2127  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C124(0.89); C122(0.77)  LDD2129  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C122(0.69)  LDD2137  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C122(1.06)  LDD2140  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C122(0.76)  LDD2141  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C122(1.52)  LDD2144  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C124(0.75)  LDD2146  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.