Details of the Target

General Information of Target

Target ID LDTP16267
Target Name Zinc finger protein 257 (ZNF257)
Gene Name ZNF257
Gene ID 113835
Synonyms
BMZF4; Zinc finger protein 257; Bone marrow zinc finger 4; BMZF-4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIMTESREVIDLDPPAETSQEQEDLFIVKVEEEDCTWMQEYNPPTFETFYQRFRHFQYHE
ASGPREALSQLRVLCCEWLRPELHTKEQILELLVLEQFLTILPEEFQPWVREHHPESGEE
AVAVIENIQRELEERRQQIVACPDVLPRKMATPGAVQESCSPHPLTVDTQPEQAPQKPRL
LEENALPVLQVPSLPLKDSQELTASLLSTGSQKLVKIEEVADVAVSFILEEWGHLDQSQK
SLYRDDRKENYGSITSMGYESRDNMELIVKQISDDSESHWVAPEHTERSVPQDPDFAEVS
DLKGMVQRWQVNPTVGKSRQNPSQKRDLDAITDISPKQSTHGERGHRCSDCGKFFLQASN
FIQHRRIHTGEKPFKCGECGKSYNQRVHLTQHQRVHTGEKPYKCQVCGKAFRVSSHLVQH
HSVHSGERPYGCNECGKNFGRHSHLIEHLKRHFREKSQRCSDKRSKNTKLSVKKKISEYS
EADMELSGKTQRNVSQVQDFGEGCEFQGKLDRKQGIPMKEILGQPSSKRMNYSEVPYVHK
KSSTGERPHKCNECGKSFIQSAHLIQHQRIHTGEKPFRCEECGKSYNQRVHLTQHQRVHT
GEKPYTCPLCGKAFRVRSHLVQHQSVHSGERPFKCNECGKGFGRRSHLAGHLRLHSREKS
HQCRECGEIFFQYVSLIEHQVLHMGQKNEKNGICEEAYSWNLTVIEDKKIELQEQPYQCD
ICGKAFGYSSDLIQHYRTHTAEKPYQCDICRENVGQCSHTKQHQKIYSSTKSHQCHECGR
GFTLKSHLNQHQRIHTGEKPFQCKECGMNFSWSCSLFKHLRSHERTDPINTLSVEGSLL
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q9Y2Q1
Ensemble ID
ENST00000594947.6
HGNC ID
HGNC:13498

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
786O Substitution: p.C126H .
A2780 Substitution: p.C126H .
CAL51 Substitution: p.C126H; p.G128Q .
CAL72 Substitution: p.E83K; p.Q96_K97delinsPE .
CAMA1 Substitution: p.C126H .
CAOV3 Substitution: p.C126H .
CCK81 Substitution: p.C126H .
DETROIT562 Substitution: p.C126H .
EFO21 SNV: p.M77T .
FUOV1 Substitution: p.C126H; p.G128Q .
G401 Substitution: p.C126H; p.G128Q .
GB1 Substitution: p.C126H .
HCC15 Substitution: p.C126H .
HCC1954 SNV: p.T360P .
HCT15 SNV: p.V41I;p.A538T
Substitution: p.C126H		 .
HT1376 Substitution: p.C126H; p.G128Q .
HT29 Substitution: p.C126H .
Ishikawa (Heraklio) 02 ER Substitution: p.C126H; p.G128Q .
JURKAT SNV: p.P523H .
KU1919 Substitution: p.C126H; p.G128Q .
L428 SNV: p.S241F .
LNCaP clone FGC SNV: p.W18Ter; p.K460N .
MCC13 SNV: p.R38K .
MDAMB453 Substitution: p.Q96_K97delinsPE .
MEWO SNV: p.W18Ter .
MFE280 Substitution: p.C126H; p.G128Q .
MM1S Substitution: p.C126H .
MV411 Substitution: p.C126H .
NCIH1048 Substitution: p.C126H .
NCIH2052 Substitution: p.C126H .
NCIH2122 Substitution: p.C126H .
NCIN87 Substitution: p.C126H .
OCIAML2 SNV: p.A414P .
OVK18 Substitution: p.C126H .
PANC0403 SNV: p.K457T .
PATU8988T Substitution: p.C126H .
REC1 Substitution: p.C126H .
RL SNV: p.K429N .
SBC5 Substitution: p.C126H; p.G128Q .
SCC25 Substitution: p.C126H .
SHP77 Substitution: p.C126H .
SKMEL24 Substitution: p.C126H .
SUIT2 Substitution: p.C126H; p.G128Q .
SW756 SNV: p.S158L .
TE1 Substitution: p.C126H; p.G128Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-465
 Probe Info  		K314(0.00); K317(0.00); Y316(0.00)  LDD2240  [1]

References

1 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010