Details of the Target
General Information of Target
| Target ID | LDTP16246 | |||||
|---|---|---|---|---|---|---|
| Target Name | Protocadherin gamma-C3 (PCDHGC3) | |||||
| Gene Name | PCDHGC3 | |||||
| Gene ID | 5098 | |||||
| Synonyms |
PCDH2; Protocadherin gamma-C3; PCDH-gamma-C3; Protocadherin-2; Protocadherin-43; PC-43 |
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| 3D Structure | ||||||
| Sequence |
MAVRELCFPRQRQVLFLFLFWGVSLAGSGFGRYSVTEETEKGSFVVNLAKDLGLAEGELA
ARGTRVVSDDNKQYLLLDSHTGNLLTNEKLDREKLCGPKEPCMLYFQILMDDPFQIYRAE LRVRDINDHAPVFQDKETVLKISENTAEGTAFRLERAQDPDGGLNGIQNYTISPNSFFHI NISGGDEGMIYPELVLDKALDREEQGELSLTLTALDGGSPSRSGTSTVRIVVLDVNDNAP QFAQALYETQAPENSPIGFLIVKVWAEDVDSGVNAEVSYSFFDASENIRTTFQINPFSGE IFLRELLDYELVNSYKINIQAMDGGGLSARCRVLVEVLDTNDNPPELIVSSFSNSVAENS PETPLAVFKINDRDSGENGKMVCYIQENLPFLLKPSVENFYILITEGALDREIRAEYNIT ITVTDLGTPRLKTEHNITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDS GTNAQVTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEALQAFEFRVGATDRGSPA LSREALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNA WLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHL LLVDGFSQPYLPLPEAAPAQAQAEADLLTVYLVVALASVSSLFLLSVLLFVAVRLCRRSR AASVGRCSVPEGPFPGHLVDVRGAETLSQSYQYEVCLTGGPGTSEFKFLKPVISDIQAQG PGRKGEENSTFRNSFGFNIQ |
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| Target Bioclass |
Other
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| Subcellular location |
Cell membrane
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| Function | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| CCLP1 | SNV: p.P155L | DBIA Probe Info | |||
| HEC1B | SNV: p.A744V | . | |||
| HT115 | SNV: p.A598V | . | |||
| LS180 | SNV: p.D597G | . | |||
| MEWO | SNV: p.R491W | DBIA Probe Info | |||
| MFE296 | Deletion: p.R684GfsTer15 | . | |||
| NALM6 | SNV: p.A598T | DBIA Probe Info | |||
| SUPT1 | Deletion: p.R684GfsTer15 | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C336(3.21) | LDD3314 | [1] | |
Competitor(s) Related to This Target