General Information of Target

Target ID LDTP16244
Target Name Protocadherin beta-8 (PCDHB8)
Gene Name PCDHB8
Gene ID 56128
Synonyms
PCDH3I; Protocadherin beta-8; PCDH-beta-8; Protocadherin-3I
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MRASPCISQPAASWHPRPSALRPTAGSGPDTRTPGTVEDGSAPCPAFRSPAVSPCGEEPC
CFQISPAEETLELGRLVSPGNCDTLSPRAAGFYACHVRSLIPCRSTKGRWPLTASAAGLS
SFSG
Target Bioclass
Other
Subcellular location
Cell membrane
Function
Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain.
Uniprot ID
Q9UN66
Ensemble ID
ENST00000239444.4
HGNC ID
HGNC:8693

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C384(1.51)  LDD3344  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 22RV1 C384(2.38)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C384(6.19)  LDD2660  [1]
 LDCM0024  KB05 NCI-H146 C384(1.51)  LDD3344  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840