Details of the Target

General Information of Target

Target ID	LDTP16238
Target Name	RING finger protein 150 (RNF150)
Gene Name	RNF150
Gene ID	57484
Synonyms	KIAA1214; RING finger protein 150
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MTSERSRIPCLSAAAAEGTGKKQQEGRAMATLDRKVPSPEAFLGKPWSSWIDAAKLHCSD NVDLEEAGKEGGKSREVMRLNKEDMHLFGHYPAHDDFYLVVCSACNQVVKPQVFQSHCER RHGSMCRPSPSPVSPASNPRTSLVQVKTKACLSGHHSASSTSKPFKTPKDNLLTSSSKQH TVFPAKGSRDKPCVPVPVVSLEKIPNLVKADGANVKMNSTTTTAVSASSTSSSAVSTPPL IKPVLMSKSVPPSPEKILNGKGILPTTIDKKHQNGTKNSNKPYRRLSEREFDPNKHCGVL DPETKKPCTRSLTCKTHSLSHRRAVPGRKKQFDLLLAEHKAKSREKEVKDKEHLLTSTRE ILPSQSGPAQDSLLGSSGSSGPEPKVASPAKSRPPNSVLPRPSSANSISSSTSSNHSGHT PEPPLPPVGGDLASRLSSDEGEMDGADESEKLDCQFSTHHPRPLAFCSFGSRLMGRGYYV FDRRWDRFRFALNSMVEKHLNSQMWKKIPPAADSPLPSPAAHITTPVPASVLQPFSNPSA VYLPSAPISSRLTSSYIMTSAMLSNAAFVTSPDPSALMSHTTAFPHVAATLSIMDSTFKA PSAVSPIPAVIPSPSHKPSKTKTSKSSKVKDLSTRSDESPSNKKRKPQSSTSSSSSSSSS SLQTSLSSPLSGPHKKNCVLNASSALNSYQAAPPYNSLSVHNSNNGVSPLSAKLEPSGRT SLPGGPADIVRQVGAVGGSSDSCPLSVPSLALHAGDLSLASHNAVSSLPLSFDKSEGKKR KNSSSSSKACKITKMPGMNSVHKKNPPSLLAPVPDPVNSTSSRQVGKNSSLALSQSSPSS ISSPGHSRQNTNRTGRIRTLP
Target Bioclass	Enzyme
Subcellular location	Membrane
Uniprot ID	Q9ULK6
Ensemble ID	ENST00000306799.7
HGNC ID	HGNC:23138

Target Site Mutations in Different Cell Lines

Cell line	Mutation details	Probe for labeling this protein in this cell
A2058	SNV: p.V218I	.
HCC827	SNV: p.H97Q	.
HEC1B	SNV: p.R129G	.
HT1197	SNV: p.S208L	.
JEKO1	SNV: p.A252T	.
KMCH1	SNV: p.P172T	.
KNS81FD	SNV: p.D242G	.
MFE319	SNV: p.V305A	.
NCIH1792	SNV: p.Q380K	.
NCIH2286	SNV: p.G78Ter	.
NCIH716	SNV: p.A119D	.
RL	SNV: p.A42T	.
SBC5	SNV: p.G75R	.
SW1271	SNV: p.C102R	.

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 1 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
IA-alkyne Probe Info			C102(11.22)	LDD1703	[1]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0022	KB02	T cell	C102(11.22)	LDD1703	[1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme

Click To Hide/Show 2 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Histone acetyltransferase KAT5 (KAT5)				MYST (SAS/MOZ) family	Q92993
Protein kinase C alpha type (PRKCA)				AGC Ser/Thr protein kinase family	P17252

Transporter and channel

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
14-3-3 protein gamma (YWHAG)				14-3-3 family	P61981

Other

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
TPA-induced transmembrane protein (TTMP)				.	Q5BVD1

References

1	An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.