Details of the Target
General Information of Target
| Target ID | LDTP16228 | |||||
|---|---|---|---|---|---|---|
| Target Name | Angiopoietin-related protein 2 (ANGPTL2) |
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| Gene Name | ANGPTL2 | |||||
| Gene ID | 23452 | |||||
| Synonyms |
ARP2; Angiopoietin-related protein 2; Angiopoietin-like protein 2 |
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| 3D Structure | ||||||
| Sequence |
MKRNSLSVENKIVQLSGAAKQPKVGFYSSLNQTHTHTVLLDWGSLPHHVVLQIFQYLPLL
DRACASSVCRRWNEVFHISDLWRKFEFELNQSATSSFKSTHPDLIQQIIKKHFAHLQYVS FKVDSSAESAEAACDILSQLVNCSIQTLGLISTAKPSFMNVSESHFVSALTVVFINSKSL SSIKIEDTPVDDPSLKILVANNSDTLRLPKMSSCPHVSSDGILCVADRCQGLRELALNYY ILTDELFLALSSETHVNLEHLRIDVVSENPGQIKFHAVKKHSWDALIKHSPRVNVVMHFF LYEEEFETFFKEETPVTHLYFGRSVSKVVLGRVGLNCPRLIELVVCANDLQPLDNELICI AEHCTNLTALGLSKCEVSCSAFIRFVRLCERRLTQLSVMEEVLIPDEDYSLDEIHTEVSK YLGRVWFPDVMPLW |
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| Target Bioclass |
Other
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| Subcellular location |
Secreted
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| Function | Induces sprouting in endothelial cells through an autocrine and paracrine action. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| AN3CA | SNV: p.L142R | . | |||
| HT | SNV: p.K45R | . | |||
| JURKAT | SNV: p.R399C | . | |||
| LOXIMVI | SNV: p.N300S | DBIA Probe Info | |||
| MCC13 | SNV: p.S267F | . | |||
| MFE319 | SNV: p.A382T | . | |||
| T98G | SNV: p.S118N | . | |||
| TOV21G | Deletion: p.A219LfsTer30 | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C70(4.83) | LDD3323 | [1] | |
Competitor(s) Related to This Target