Details of the Target

General Information of Target

Target ID LDTP16214
Target Name Zinc finger protein 229 (ZNF229)
Gene Name ZNF229
Gene ID 7772
Synonyms
Zinc finger protein 229
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MERARRRGGGGGRGRGGKNVGGSGLSKSRLYPQAQHSHYPHYAASATPNQAGGAAEIQEL
ASKRVDIQKKRFYLDVKQSSRGRFLKIAEVWIGRGRQDNIRKSKLTLSLSVAAELKDCLG
DFIEHYAHLGLKGHRQEHGHSKEQGSRRRQKHSAPSPPVSVGSEEHPHSVLKTDYIERDN
RKYYLDLKENQRGRFLRIRQTMMRGTGMIGYFGHSLGQEQTIVLPAQGMIEFRDALVQLI
EDYGEGDIEERRGGDDDPLELPEGTSFRVDNKRFYFDVGSNKYGIFLKVSEVRPPYRNTI
TVPFKAWTRFGENFIKYEEEMRKICNSHKEKRMDGRKASGEEQECLD
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q9UJW7
Ensemble ID
ENST00000613197.4
HGNC ID
HGNC:13022

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8305C SNV: p.G469R .
FUOV1 SNV: p.D136V .
HCC1187 SNV: p.Y377S .
HCT15 SNV: p.T735N .
HGC27 SNV: p.F358S .
HT115 SNV: p.D38G; p.Q172H .
IPC298 SNV: p.Q675Ter .
Ishikawa (Heraklio) 02 ER Deletion: p.Q172VfsTer32 .
MCC13 SNV: p.G355E .
MFE319 SNV: p.V761A .
NCIH1793 SNV: p.Q421P .
NCIH1944 SNV: p.G387D .
SG231 SNV: p.G327D .
SNU5 SNV: p.R700L .
TGBC52TKB SNV: p.G469R .
U87MG SNV: p.Q16K .
UACC257 SNV: p.I153M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-465
 Probe Info  		K543(0.00); K546(0.00); Y545(0.00)  LDD2240  [1]

References

1 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010