Details of the Target

General Information of Target

Target ID LDTP16176
Target Name Protein unc-79 homolog (UNC79)
Gene Name UNC79
Gene ID 57578
Synonyms
KIAA1409; Protein unc-79 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQRPEAWPRPHPGEGAAAAQAGGPAPPARAGEPSGLRLQEPSLYTIKAVFILDNDGRRLL
AKYYDDTFPSMKEQMVFEKNVFNKTSRTESEIAFFGGMTIVYKNSIDLFLYVVGSSYENE
LMLMSVLTCLFESLNHMLRKNVEKRWLLENMDGAFLVLDEIVDGGVILESDPQQVIQKVN
FRADDGGLTEQSVAQVLQSAKEQIKWSLLK
Target Bioclass
Transporter and channel
Family
Unc-79 family
Subcellular location
Cell membrane
Function
Auxiliary subunit of the NALCN sodium channel complex, a voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability. Activated by neuropeptides substance P, neurotensin, and extracellular calcium that regulates neuronal excitability by controlling the sizes of NALCN-dependent sodium-leak current.
Uniprot ID
Q9P2D8
Ensemble ID
ENST00000256339.8
HGNC ID
HGNC:19966

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0166  [1]

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060