General Information of Target

Target ID LDTP16133
Target Name Rho guanine nucleotide exchange factor 38 (ARHGEF38)
Gene Name ARHGEF38
Gene ID 54848
Synonyms
Rho guanine nucleotide exchange factor 38
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATLVELPDSVLLEIFSYLPVRDRIRISRVCHRWKRLVDDRWLWRHVDLTLYTMRPKVMW
HLLRRYMASRLHSLRMGGYLFSGSQAPQLSPALLRALGQKCPNLKRLCLHVADLSMVPIT
SLPSTLRTLELHSCEISMAWLHKQQDPTVLPLLECIVLDRVPAFRDEHLQGLTRFRALRS
LVLGGTYRVTETGLDAGLQELSYLQRLEVLGCTLSADSTLLAISRHLRDVRKIRLTVRGL
SAPGLAVLEGMPALESLCLQGPLVTPEMPSPTEILSSCLTMPKLRVLELQGLGWEGQEAE
KILCKGLPHCMVIVRACPKESMDWWM
Target Bioclass
Other
Function May act as a guanine-nucleotide releasing factor.
Uniprot ID
Q9NXL2
Ensemble ID
ENST00000265154.6
HGNC ID
HGNC:25968

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C447(1.84)  LDD2268  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 BRX211 C447(1.84)  LDD2268  [1]
 LDCM0023  KB03 BRX250 C447(2.19)  LDD2686  [1]
 LDCM0024  KB05 BRX250 C447(2.49)  LDD3103  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840