Details of the Target

General Information of Target

Target ID LDTP16086
Target Name Semaphorin-3G (SEMA3G)
Gene Name SEMA3G
Gene ID 56920
Synonyms
Semaphorin-3G; Semaphorin sem2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGFLQLLVVAVLASEHRVAGAAEVFGNSSEGLIEFSVGKFRYFELNRPFPEEAILHDISS
NVTFLIFQIHSQYQNTTVSFSPTLLSNSSETGTASGLVFILRPEQSTCTWYLGTSGIQPV
QNMAILLSYSERDPVPGGCNLEFDLDIDPNIYLEYNFFETTIKFAPANLGYARGVDPPPC
DAGTDQDSRWRLQYDVYQYFLPENDLTEEMLLKHLQRMVSVPQVKASALKVVTLTANDKT
SVSFSSLPGQGVIYNVIVWDPFLNTSAAYIPAHTYACSFEAGEGSCASLGRVSSKVFFTL
FALLGFFICFFGHRFWKTELFFIGFIIMGFFFYILITRLTPIKYDVNLILTAVTGSVGGM
FLVAVWWRFGILSICMLCVGLVLGFLISSVTFFTPLGNLKIFHDDGVFWVTFSCIAILIP
VVFMGCLRILNILTCGVIGSYSVVLAIDSYWSTSLSYITLNVLKRALNKDFHRAFTNVPF
QTNDFIILAVWGMLAVSGITLQIRRERGRPFFPPHPYKLWKQERERRVTNILDPSYHIPP
LRERLYGRLTQIKGLFQKEQPAGERTPLLL
Target Bioclass
Immunoglobulin
Family
Semaphorin family
Subcellular location
Secreted
Function Has chemorepulsive activities for sympathetic axons. Ligand of NRP2.
Uniprot ID
Q9NS98
Ensemble ID
ENST00000231721.7
HGNC ID
HGNC:30400

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C529(1.18); C532(1.18)  LDD0078  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0020  ARS-1620 HCC44 C529(1.18); C532(1.18)  LDD0078  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.