Details of the Target

General Information of Target

Target ID LDTP16081
Target Name Sperm protein associated with the nucleus on the X chromosome B1 (SPANXB1)
Gene Name SPANXB1
Gene ID 728695
Synonyms
SPANXB; SPANXB2; SPANXF1; Sperm protein associated with the nucleus on the X chromosome B1; Cancer/testis antigen 11.2; CT11.2; Nuclear-associated protein SPAN-Xb; SPANX-B; SPANX family member B1; SPANX family member F1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSDKDDIETPLLTEAAPILEDGNCEPAKNSESVDQGAKPESKSEPVVSTRKRPETKPSSD
LETSKVLPIQDNVSKDVPQTRWGYWGSWGKSILSSASATVATVGQGISNVIEKAETSLGI
PGPSEISTEVKYVAGETNAKENENSSPVAGAFGVFSTISTAVQSTGKSVISGGLDALEFI
GKKTMDVIAEGDPGFKRTKGLMNRNATLSQVLREAKEKEEIRTSNEVTVETDKKTHYGLL
FDEFQGLSHLEALEMLSQESEIKVKSILNSLSGEELETLKVELEQLKETFSLAEFCEEEE
EEKKGDEDFTKDITELFSQLHVSSKPEKLARARNTAHEWIRKSLTKPLAENEEGEKQSEA
ENTEQVNKNSIEDIHAFAIRSLAELTACSIELFHKTAALVLHGRKQEVTAIERSQTLSQM
TIVLCKELSSLSKEFTTCLTTAGVKEMADVLNPLITAVFLEASNSASYIQDAFQLLLPVL
EISLIENKIESHRHELQGQKPLLEH
Target Bioclass
Other
Family
SPAN-X family
Subcellular location
Cytoplasm
Uniprot ID
Q9NS25
Ensemble ID
ENST00000449283.2
HGNC ID
HGNC:14329

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C16(3.09)  LDD3414  [1]
NAIA_4
 Probe Info  		N.A.  LDD2226  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 D283 Med C16(1.73)  LDD2312  [1]
 LDCM0023  KB03 D283 Med C16(5.49)  LDD2729  [1]
 LDCM0024  KB05 SAOS-2 C16(3.09)  LDD3414  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264