Details of the Target

General Information of Target

Target ID LDTP16077
Target Name Metal transporter CNNM1 (CNNM1)
Gene Name CNNM1
Gene ID 26507
Synonyms
ACDP1; Metal transporter CNNM1; Ancient conserved domain-containing protein 1; Cyclin-M1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRTPGPLPVLLLLLAGAPAARPTPPTCYSRMRALSQEITRDFNLLQVSEPSEPCVRYLPR
LYLDIHNYCVLDKLRDFVASPPCWKVAQVDSLKDKARKLYTIMNSFCRRDLVFLLDDCNA
LEYPIPVTTVLPDRQR
Target Bioclass
Transporter and channel
Family
ACDP family
Subcellular location
Cell membrane
Function Probable metal transporter.
Uniprot ID
Q9NRU3
Ensemble ID
ENST00000356713.5
HGNC ID
HGNC:102

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.E682D .
HCT15 SNV: p.T552M .
HEC1 SNV: p.R463H .
HEC1B SNV: p.R463H .
HT SNV: p.T61A .
HUH7 SNV: p.L45P .
ICC3 SNV: p.E540D .
Ishikawa (Heraklio) 02 ER Deletion: p.G60AfsTer174
SNV: p.L609F		 .
JURKAT SNV: p.A298V .
KYSE410 SNV: p.S454F .
LS180 SNV: p.A158S .
MCC13 SNV: p.D567N .
MEWO SNV: p.Y461Ter .
MFE319 SNV: p.T705A .
NCIH1993 SNV: p.S245I .
NCIH716 SNV: p.Y461Ter .
OVCAR8 SNV: p.R402W .
OVK18 SNV: p.S759N .
REH SNV: p.P375L .
RKO SNV: p.D405V .
SNGM SNV: p.G460S; p.T813I .
SW620 SNV: p.H281Q .
VMRCRCW SNV: p.K482R .
WM115 SNV: p.E658K .
WM2664 SNV: p.E658K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C733(1.87)  LDD3483  [1]
IPM
 Probe Info  		C733(2.36)  LDD1702  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C733(2.36)  LDD1702  [2]
 LDCM0022  KB02 G-361 C733(2.12)  LDD2329  [1]
 LDCM0023  KB03 G-361 C733(2.77)  LDD2746  [1]
 LDCM0024  KB05 UACC-257 C733(1.87)  LDD3483  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761