Details of the Target

General Information of Target

Target ID LDTP16075
Target Name Olfactomedin-like protein 3 (OLFML3)
Gene Name OLFML3
Gene ID 56944
Synonyms
Olfactomedin-like protein 3; HNOEL-iso; hOLF44
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAASKTQGAVARMQEDRDGSCSTVGGVGYGDSKDCILEPLSLPESPGGTTTLEGSPSVPC
IFCEEHFPVAEQDKLLKHMIIEHKIVIADVKLVADFQRYILYWRKRFTEQPITDFCSVIR
INSTAPFEEQENYFLLCDVLPEDRILREELQKQRLREILEQQQQERNDTNFHGVCMFCNE
EFLGNRSVILNHMAREHAFNIGLPDNIVNCNEFLCTLQKKLDNLQCLYCEKTFRDKNTLK
DHMRKKQHRKINPKNREYDRFYVINYLELGKSWEEVQLEDDRELLDHQEDDWSDWEEHPA
SAVCLFCEKQAETIEKLYVHMEDAHEFDLLKIKSELGLNFYQQVKLVNFIRRQVHQCRCY
GCHVKFKSKADLRTHMEETKHTSLLPDRKTWDQLEYYFPTYENDTLLCTLSDSESDLTAQ
EQNENVPIISEDTSKLYALKQSSILNQLLL
Target Bioclass
Other
Family
OLFML3 family
Subcellular location
Secreted
Function
Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation. May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes.
Uniprot ID
Q9NRN5
Ensemble ID
ENST00000320334.5
HGNC ID
HGNC:24956

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.L276P .
DU145 SNV: p.G211R .
HT115 SNV: p.R200Q .
IPC298 SNV: p.R89C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C347(2.47); C44(1.16)  LDD3423  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A673 C347(3.39); C44(1.84)  LDD2261  [1]
 LDCM0023  KB03 A673 C347(6.46)  LDD2678  [1]
 LDCM0024  KB05 SK-ES1 C347(2.47); C44(1.16)  LDD3423  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840