Details of the Target

General Information of Target

Target ID LDTP16067
Target Name Fascin-3 (FSCN3)
Gene Name FSCN3
Gene ID 29999
Synonyms
Fascin-3; Testis fascin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQAERGARGGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRGRGRGFR
GARGGRGGGGAPRGSRREPGGWGAGASAPVEDDSDAETYGEENDEQGNYSKRKIVSNWDR
YQDIEKEVNNESGESQRGTDFSVLLSSAGDSFSQFRFAEEKEWDSEASCPKQNSAFYVDS
ELLVRALQELPLCLRLNVAAELVQGTVPLEVPQVKPKRTDDGKGLGMQLKGPLGPGGRGP
IFELKSVAAGCPVLLGKDNPSPGPSRDSQKPTSPLQSAGDHLEEELDLLLNLDAPIKEGD
NILPDQTSQDLKSKEDGEVVQEEEVCAKPSVTEEKNMEPEQPSTSKNVTEEELEDWLDSM
IS
Target Bioclass
Other
Family
Fascin family
Subcellular location
Cytoplasm, cytoskeleton
Function Acts as an actin bundling protein.
Uniprot ID
Q9NQT6
Ensemble ID
ENST00000265825.6
HGNC ID
HGNC:3961

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC15 SNV: p.R322L .
HCC1954 SNV: p.N249D .
HT115 SNV: p.E497Ter .
JVM3 SNV: p.E59Ter .
L428 SNV: p.G396S .
NCIH1792 SNV: p.R65Ter .
OVK18 SNV: p.P306H .
SBC5 SNV: p.F198L .
U937 Substitution: p.G359S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C353(0.94)  LDD2127  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C353(0.94)  LDD2127  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761