General Information of Target

Target ID LDTP16051
Target Name Endogenous retrovirus group K member 5 Gag polyprotein (ERVK-5)
Gene Name ERVK-5
Synonyms
ERVK5; Endogenous retrovirus group K member 5 Gag polyprotein; HERV-K(II) Gag protein; HERV-K_3q12.3 provirus ancestral Gag polyprotein; Gag polyprotein
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MESPKKKNQQLKVGILHLGSRQKKIRIQLRSQCATWKVICKSCISQTPGINLDLGSGVKV
KIIPKEEHCKMPEAGEEQPQV
Target Bioclass
Other
Family
Beta type-B retroviral Gag protein family, HERV class-II K(HML-2) gag subfamily
Subcellular location
Cell membrane
Function
The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.
Uniprot ID
Q9HDB9
HGNC ID
HGNC:13757

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info 
C558(1.17)  LDD2135  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C558(1.17)  LDD2135  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761