Details of the Target

General Information of Target

Target ID LDTP16050
Target Name X antigen family member 1 (XAGE1A; XAGE1B)
Gene Name XAGE1A; XAGE1B
Gene ID 653067
Synonyms
GAGED2; XAGE1; XAGE1C; XAGE1D; XAGE1E; X antigen family member 1; XAGE-1; Cancer/testis antigen 12.1; CT12.1; G antigen family D member 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAGLALLCRRVSSALKSSRSLITPQVPACTGFFLSLLPKSTPNVTSFHQYRLLHTTLS
RKGLEEFFDDPKNWGQEKVKSGAAWTCQQLRNKSNEDLHKLWYVLLKERNMLLTLEQEAK
RQRLPMPSPERLDKVVDSMDALDKVVQEREDALRLLQTGQERARPGAWRRDIFGRIIWHK
FKQWVIPWHLNKRYNRKRFFALPYVDHFLRLEREKRARIKARKENLERKKAKILLKKFPH
LAEAQKSSLV
Target Bioclass
Other
Family
GAGE family
Uniprot ID
Q9HD64
Ensemble ID
ENST00000375600.5
HGNC ID
HGNC:4111
ChEMBL ID
CHEMBL4295952

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C43(2.50)  LDD3316  [1]
NAIA_4
 Probe Info  		N.A.  LDD2226  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 CC-SW-1 C43(1.46)  LDD2299  [1]
 LDCM0023  KB03 A673 C33(1.39)  LDD2678  [1]
 LDCM0024  KB05 MEL167 C43(2.50)  LDD3316  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264