Details of the Target

General Information of Target

Target ID LDTP16045
Target Name Protocadherin-18 (PCDH18)
Gene Name PCDH18
Gene ID 54510
Synonyms
KIAA1562; Protocadherin-18
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGDPGSEIIESVPPAGPEASESTTDENEDDIQFVSEGPSRPVLEYIDLVCGDDENPSAYY
SDILFPKMPKRQGDFLHFLNVKKVKTDTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKP
SLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLGSKAEKHVHV
SKEWIAYLVTPNGSNKTTRQASLRKKIREHDVSKAHGKIQDLLKESTNDSICNLVHKQNN
KNIDATVKVFNTVYSLVKHNRPLSDIEGARELQEKNGEVNCLNTRYSATRIAEHIAKEMK
MKIFKNIIEENAKICIIIDEASTVSKKTTLVIYLQCTIQSAPAPVMLFVALKELVSTIAE
CIVNTLLTTLNDCGFTNEYLKANLIAFCSDGANTILGRKSGVATKLLENFPEIIIWNCLN
HRLQLSLDDSISEIKQINHLKIFIDKIYSIYHQPNKNQTKLLGTVAKELETEIIKIGRVM
GPRWAACSLQAATAVWHAYPILYMHFSHSYSGLAKRLANINFLQDLALMIDILEEFSVLS
TALQSRSTNIKKAQKLIKRTIRALENLKIGTGKYESQIEDLIKSDKFKDIPFNKNNKFNA
LPRSILLDNIIQHMNLRLLSDRNHEDIFNYFDLLEPSTWPYEEITSPWIAGEKTLFHLCK
ILKYEVDLNDFREFVNNNIKSNNVSIPTTIYKAKKIVSTIAINSAEAERGFNLMNIICTR
VRNSLTIDHVSDLMTINLLGKELADWDATPFVKSWSNCNHRLATDTRVRQKSTKVFHENQ
LAIWNLK
Target Bioclass
Other
Subcellular location
Cell membrane
Function Potential calcium-dependent cell-adhesion protein.
Uniprot ID
Q9HCL0
Ensemble ID
ENST00000344876.9
HGNC ID
HGNC:14268

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL33 SNV: p.A68T .
CCLP1 SNV: p.E537Ter .
COLO320 SNV: p.G791A .
CORL88 Deletion: p.Ter1136RfsTer4 .
DU145 SNV: p.S432T; p.G951W .
HT115 SNV: p.R46I .
HUPT4 SNV: p.S360F; p.S818P .
IGR1 SNV: p.R67Ter .
JURKAT SNV: p.S286N .
KYSE150 SNV: p.R723S .
KYSE410 SNV: p.R850Ter; p.S891F .
LN18 SNV: p.Y411H .
MCC13 SNV: p.G525R .
NCIH1793 SNV: p.Q1013L .
NCIH3122 SNV: p.M717V .
SKMEL24 SNV: p.D998N .
SKMEL5 SNV: p.Q1130R .
SNU869 SNV: p.E1124D .
WM2664 Insertion: p.R548KfsTer21 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C931(2.76)  LDD3398  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A-172 C931(0.89)  LDD2251  [1]
 LDCM0023  KB03 42-MG-BA C931(1.48)  LDD2661  [1]
 LDCM0024  KB05 PFSK-1 C931(2.76)  LDD3398  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840