Details of the Target

General Information of Target

Target ID LDTP16001
Target Name IGF-like family receptor 1 (IGFLR1)
Gene Name IGFLR1
Gene ID 79713
Synonyms
TMEM149; U2AF1L4; IGF-like family receptor 1; Transmembrane protein 149; U2 small nuclear RNA auxiliary factor 1-like 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEDPNPEENMKQQDSPKERSPQSPGGNICHLGAPKCTRCLITFADSKFQERHMKREHPAD
FVAQKLQGVLFICFTCARSFPSSKALITHQRSHGPAAKPTLPVATTTAQPTFPCPDCGKT
FGQAVSLRRHRQMHEVRAPPGTFACTECGQDFAQEAGLHQHYIRHARGEL
Target Bioclass
Other
Subcellular location
Cell membrane
Function Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2.
Uniprot ID
Q9H665
Ensemble ID
ENST00000246532.6
HGNC ID
HGNC:23620
ChEMBL ID
CHEMBL2029192

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Deletion: p.P72RfsTer26 .
DU145 SNV: p.Y289C .
DU4475 SNV: p.I264M .
Ishikawa (Heraklio) 02 ER SNV: p.F161I .
JHH1 SNV: p.G66C .
MDAMB468 SNV: p.G205A .
NALM6 SNV: p.R138H .
NCIH2170 SNV: p.L183M .
PC9 SNV: p.P163L .
SISO SNV: p.T100I .
SKMEL28 Substitution: p.G105E .
SUPT1 SNV: p.L180P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C42(8.35)  LDD2157  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Insulin growth factor-like family member 1 (IGFL1) IGFL family Q6UW32

References

1 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151