Details of the Target

General Information of Target

Target ID LDTP15996
Target Name Serine hydrolase-like protein 2 (SERHL2)
Gene Name SERHL2
Gene ID 253190
Synonyms
SERHL; Serine hydrolase-like protein 2; EC 3.1.-.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLGLPWKGGLSWALLLLLLGSQILLIYAWHFHEQRDCDEHNVMARYLPATVEFAVHTFNQ
QSKDYYAYRLGHILNSWKEQVESKTVFSMELLLGRTRCGKFEDDIDNCHFQESTELNNTF
TCFFTISTRPWMTQFSLLNKTCLEGFH
Target Bioclass
Enzyme
Family
AB hydrolase superfamily
Subcellular location
Cytoplasm, perinuclear region
Function Probable serine hydrolase. May be related to cell muscle hypertrophy.
Uniprot ID
Q9H4I8
Ensemble ID
ENST00000327678.10
HGNC ID
HGNC:29446

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KARPAS299 SNV: p.M309L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C49(3.88)  LDD3493  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 AU565 C49(1.95)  LDD2265  [1]
 LDCM0023  KB03 AU565 C49(2.42)  LDD2682  [1]
 LDCM0024  KB05 ZR-75-1 C49(3.88)  LDD3493  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840