Details of the Target

General Information of Target

Target ID LDTP15992
Target Name RWD domain-containing protein 1 (RWDD1)
Gene Name RWDD1
Gene ID 51389
Synonyms
DFRP2; RWD domain-containing protein 1; DRG family-regulatory protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MERSQSRLSLSASFEALAIYFPCMNSFDDEDAGDSRRLKGAIQRSTETGLAVEMPSRTLR
QASHESIEDSMNSYGSEGNLNYGGVCLASDAQFSDFLGSMGPAQFVGRQTLATTPMGDVE
IGLQERNGQLEVDIIQARGLTAKPGSKTLPAAYIKAYLLENGICIAKKKTKVARKSLDPL
YNQVLLFPESPQGKVLQVIVWGNYGRMERKQFMGVARVLLEELDLTTLAVGWYKLFPTSS
MVDPATGPLLRQASQLSLESTVGPCGERS
Target Bioclass
Other
Family
RWDD1/GIR2 family
Function Protects DRG2 from proteolytic degradation.
Uniprot ID
Q9H446
Ensemble ID
ENST00000466444.7
HGNC ID
HGNC:20993

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HL60 SNV: p.Y19S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K157(10.00)  LDD0277  [1]
m-APA
 Probe Info  		N.A.  LDD2231  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377