Details of the Target
General Information of Target
| Target ID | LDTP15964 | |||||
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| Target Name | Adenosine 3'-phospho 5'-phosphosulfate transporter 2 (SLC35B3) | |||||
| Gene Name | SLC35B3 | |||||
| Gene ID | 51000 | |||||
| Synonyms |
C6orf196; PAPST2; Adenosine 3'-phospho 5'-phosphosulfate transporter 2; 3'-phosphoadenosine 5'-phosphosulfate transporter; PAPS transporter 2; Solute carrier family 35 member B3 |
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| 3D Structure | ||||||
| Sequence |
MLANSSSTNSSVLPCPDYRPTHRLHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVY
MCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRY AAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFS DELWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANL VIFLLCFVPYNSTLAVYGLLRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFS AEGFRNTLRGLGTPHRARTSATNGTRAALAQSERSAVTTDATRPDAASQGLLRPSDSHSL SSFTQCPQDSAL |
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| Target Bioclass |
Transporter and channel
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| Family |
Nucleotide-sugar transporter family, SLC35B subfamily
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| Subcellular location |
Golgi apparatus membrane
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| Function |
Probably functions as a 3'-phosphoadenylyl sulfate:adenosine 3',5'-bisphosphate antiporter at the Golgi membranes. Mediates the transport from the cytosol into the lumen of the Golgi of 3'-phosphoadenylyl sulfate/adenosine 3'-phospho 5'-phosphosulfate (PAPS), a universal sulfuryl donor for sulfation events that take place in that compartment.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
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Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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STPyne Probe Info |
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K387(3.48) | LDD0277 | [1] | |