Details of the Target

General Information of Target

Target ID LDTP15928
Target Name Keratin, type I cytoskeletal 23 (KRT23)
Gene Name KRT23
Gene ID 25984
Synonyms
Keratin, type I cytoskeletal 23; Cytokeratin-23; CK-23; Keratin-23; K23
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRTDSSKMTDVESGVANFASSARAGRRNALPDIQSSAATDGTSDLPLKLEALSVKEDAKE
KDEKTTQDQLEKPQNEEK
Target Bioclass
Other
Family
Intermediate filament family
Uniprot ID
Q9C075
Ensemble ID
ENST00000209718.8
HGNC ID
HGNC:6438

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ECC2 SNV: p.E385K DBIA    Probe Info 
HEC1 SNV: p.V188I .
HEC1B SNV: p.V188I .
KU1919 SNV: p.E417K .
KYSE510 SNV: p.R151T .
UACC62 SNV: p.G19R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
DBIA
 Probe Info  		C413(1.02)  LDD3323  [3]
W1
 Probe Info  		N.A.  LDD0236  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 769-P C413(1.99); C52(2.01)  LDD2246  [3]
 LDCM0023  KB03 769-P C413(2.23); C52(2.92)  LDD2663  [3]
 LDCM0024  KB05 SKMEL24 C413(1.02)  LDD3323  [3]

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840