General Information of Target

Target ID LDTP15925
Target Name Probable G-protein coupled receptor 63 (GPR63)
Gene Name GPR63
Gene ID 81491
Synonyms
PSP24B; Probable G-protein coupled receptor 63; PSP24-2; PSP24-beta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADQDPAGISPLQQMVASGTGAVVTSLFMTPLDVVKVRLQSQRPSMASELMPSSRLWSLS
YTKLPSSLQSTGKCLLYCNGVLEPLYLCPNGARCATWFQDPTRFTGTMDAFVKIVRHEGT
RTLWSGLPATLVMTVPATAIYFTAYDQLKAFLCGRALTSDLYAPMVAGALARLGTVTVIS
PLELMRTKLQAQHVSYRELGACVRTAVAQGGWRSLWLGWGPTALRDVPFSALYWFNYELV
KSWLNGFRPKDQTSVGMSFVAGGISGTVAAVLTLPFDVVKTQRQVALGAMEAVRVNPLHV
DSTWLLLRRIRAESGTKGLFAGFLPRIIKAAPSCAIMISTYEFGKSFFQRLNQDRLLGG
Target Type
Literature-reported
Target Bioclass
GPCR
Family
G-protein coupled receptor 1 family
Subcellular location
Cell membrane
Function Orphan receptor. May play a role in brain function.
TTD ID
T69393
Uniprot ID
Q9BZJ6
DrugMap ID
TT2D5VM
Ensemble ID
ENST00000229955.4
HGNC ID
HGNC:13302
ChEMBL ID
CHEMBL4523916

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY-1
 Probe Info 
K376(0.00); K377(0.00); W373(0.00)  LDD0246  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dihydrosphingosine-1-phosphate Small molecular drug D02UUO
Dioleoylphosphatidic Acid Small molecular drug D07KBZ

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.