Details of the Target

General Information of Target

Target ID LDTP15903
Target Name Sal-like protein 3 (SALL3)
Gene Name SALL3
Gene ID 27164
Synonyms
ZNF796; Sal-like protein 3; Zinc finger protein 796; Zinc finger protein SALL3; hSALL3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKLASGFLVLWLSLGGGLAQSDTSPDTEESYSDWGLRHLRGSFESVNSYFDSFLELLGGK
NGVCQYRCRYGKAPMPRPGYKPQEPNGCGSYFLGLKVPESMDLGIPAMTKCCNQLDVCYD
TCGANKYRCDAKFRWCLHSICSDLKRSLGFVSKVEAACDSLVDTVFNTVWTLGCRPFMNS
QRAACICAEEEKEEL
Target Bioclass
Transcription factor
Family
Sal C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function Probable transcription factor.
Uniprot ID
Q9BXA9
Ensemble ID
ENST00000536229.7
HGNC ID
HGNC:10527

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.D610N DBIA    Probe Info 
CAL148 SNV: p.K674N DBIA    Probe Info 
CAL51 SNV: p.A100V DBIA    Probe Info 
CAMA1 Substitution: p.A185L .
CAOV3 SNV: p.P90T .
CCSW1 SNV: p.T749I .
DEL Substitution: p.A185L .
DU145 Insertion: p.L652AfsTer147 DBIA    Probe Info 
EFO21 SNV: p.R106G DBIA    Probe Info 
FTC133 Substitution: p.A185L .
G361 Substitution: p.A185L .
HCC44 SNV: p.G496V .
HDQP1 Substitution: p.A185L DBIA    Probe Info 
HUH7 SNV: p.Q221P .
ICC137 Substitution: p.A185L DBIA    Probe Info 
ICC8 Substitution: p.A185L .
IGR1 SNV: p.M854I DBIA    Probe Info 
JHH6 SNV: p.G269R .
K562 SNV: p.D542E .
LOXIMVI SNV: p.E130K DBIA    Probe Info 
LS513 SNV: p.R239W .
MCC13 SNV: p.S43N .
MEWO SNV: p.G774S .
MOLT4 SNV: p.A29S
Substitution: p.A185L		 .
NCIH1792 Substitution: p.A185L .
NCIH1793 Substitution: p.A185L .
NCIH2286 SNV: p.R1003Q .
NCIH446 Substitution: p.A185L .
NCIH82 SNV: p.Q478R .
OV56 SNV: p.P485R .
OVCAR5 SNV: p.D489N .
OVKATE SNV: p.P894L .
PATU8988T SNV: p.A693T .
PC3 Substitution: p.A185L .
RAMOS Substitution: p.A185L .
REH SNV: p.P237L DBIA    Probe Info 
RKO Insertion: p.E92RfsTer504
Substitution: p.Q616_A617delinsHP		 .
RL952 SNV: p.N1213D DBIA    Probe Info 
SBC5 SNV: p.G1137A .
SCC25 Substitution: p.A185L .
SKOV3 SNV: p.N1227I .
TOV21G SNV: p.S662Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C999(2.45)  LDD3331  [1]
BTD
 Probe Info  		C53(0.30)  LDD2089  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
VSF
 Probe Info  		N.A.  LDD0007  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 697 C999(1.47)  LDD2245  [1]
 LDCM0023  KB03 42-MG-BA C999(1.68)  LDD2661  [1]
 LDCM0024  KB05 MKN-1 C999(2.45)  LDD3331  [1]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C53(0.33)  LDD2121  [2]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C53(0.30)  LDD2089  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C53(0.76)  LDD2099  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C53(0.88)  LDD2107  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C53(0.85)  LDD2125  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C53(1.33)  LDD2129  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C53(0.99)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C53(0.96)  LDD2137  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C53(0.61)  LDD2146  [2]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C53(0.29)  LDD2150  [2]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764