Details of the Target

General Information of Target

Target ID	LDTP15900
Target Name	Apolipoprotein L6 (APOL6)
Gene Name	APOL6
Gene ID	80830
Synonyms	Apolipoprotein L6; Apolipoprotein L-VI; ApoL-VI
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MADILSQSETLASQDLSGDFKKPALPVSPAARSKAPASSSSNPEEVQKEGPTALQDSNSG EPDIPPPQPDCGDFRSLQEEQSRPPTAVSSPGGPARAPPYQEPPWGGPATAPYSLETLKG GTILGTRSLKGTSYCLFGRLSGCDVCLEHPSVSRYHAVLQHRASGPDGECDSNGPGFYLY DLGSTHGTFLNKTRIPPRTYCRVHVGHVVRFGGSTRLFILQGPEEDREAESELTVTQLKE LRKQQQILLEKKMLGEDSDEEEEMDTSERKINAGSQDDEMGCTWGMGEDAVEDDAEENPI VLEFQQEREAFYIKDPKKALQGFFDREGEELEYEFDEQGHSTWLCRVRLPVDDSTGKQLV AEAIHSGKKKEAMIQCSLEACRILDTLGLLRQEAVSRKRKAKNWEDEDFYDSDDDTFLDR TGLIEKKRLNRMKKAGKIDEKPETFESLVAKLNDAERELSEISERLKASSQVLSESPSQD SLDAFMSEMKSGSTLDGVSRKKLHLRTFELRKEQQRLKGLIKIVKPAEIPELKKTETQTT GAENKAKKLTLPLFGAMKGGSKFKLKTGTVGKLPPKRPELPPTLMRMKDEPEVEEEEEEE EEEEKEKEEHEKKKLEDGSLSRPQPEIEPEAAVQEMRPPTDLTHFKETQTHENMSQLSEE EQNKDYQDCSKTTSLCAGPSASKNEYEKSRGELKKKKTPGPGKLPPTLSSKYPEDDPDYC VWVPPEGQSGDGRTHLNDKYGY
Target Bioclass	Other
Family	Apolipoprotein L family
Subcellular location	Cytoplasm
Function	May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.
Uniprot ID	Q9BWW8
Ensemble ID	ENST00000409652.5
HGNC ID	HGNC:14870

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 1 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
IA-alkyne Probe Info			C311(16.45)	LDD1707	[1]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0022	KB02	T cell	C311(16.45)	LDD1707	[1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme

Click To Hide/Show 2 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Protein farnesyltransferase subunit beta (FNTB)				Protein prenyltransferase subunit beta family	P49356
Germ cell-less protein-like 1 (GMCL1)				.	Q96IK5

Transporter and channel

Click To Hide/Show 2 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
CCN family member 3 (CCN3)				CCN family	P48745
AP-4 complex accessory subunit Tepsin (TEPSIN)				.	Q96N21

Other

Click To Hide/Show 3 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
Keratin-associated protein 10-8 (KRTAP10-8)	KRTAP type 10 family	P60410
Ragulator complex protein LAMTOR3 (LAMTOR3)	LAMTOR3 family	Q9UHA4
Regulator of G-protein signaling 13 (RGS13)	.	O14921

References

1	An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.