Details of the Target

General Information of Target

Target ID LDTP15897
Target Name Tubulin polymerization-promoting protein family member 3 (TPPP3)
Gene Name TPPP3
Gene ID 51673
Synonyms
Tubulin polymerization-promoting protein family member 3; TPPP/p20
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAGDVGGRSCTDSELLLHPELLSQEFLLLTLEQKNIAVETDVRVNKDSLTDLYVQHAIPL
PQRDLPKNRWGKMMEKKREQHEIKNETKRSSTVDGLRKRPLIVFDGSSTSTSIKVKKTEN
GDNDRLKPPPQASFTSNAFRKLSNSSSSVSPLILSSNLPVNNKTEHNNNDAKQNHDLTHR
KSPSGPVKSPPLSPVGTTPVKLKRAAPKEEAEAMNNLKPPQAKRKIQHVTWP
Target Bioclass
Other
Family
TPPP family
Subcellular location
Cytoplasm
Function
Regulator of microtubule dynamic that has microtubule bundling activity. Required for embryo implantation; possibly by regulating beta-catenin. Also required for decidualization via regulation of beta-catenin.
Uniprot ID
Q9BW30
Ensemble ID
ENST00000290942.9
HGNC ID
HGNC:24162

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-475
 Probe Info  		Y131(0.09)  LDD0264  [1]
HHS-465
 Probe Info  		Y131(10.00)  LDD2237  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y131(0.09)  LDD0264  [1]
 LDCM0117  HHS-0201 DM93 Y131(0.53)  LDD0265  [1]
 LDCM0119  HHS-0401 DM93 Y131(0.19)  LDD0267  [1]

References

1 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
2 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.