Details of the Target

General Information of Target

Target ID LDTP15894
Target Name Coiled-coil domain-containing protein 32 (CCDC32)
Gene Name CCDC32
Gene ID 90416
Synonyms
C15orf57; Coiled-coil domain-containing protein 32
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEDAAAPGRTEGVLERQGAPPAAGQGGALVELTPTPGGLALVSPYHTHRAGDPLDLVALA
EQVQKADEFIRANATNKLTVIAEQIQHLQEQARKVLEDAHRDANLHHVACNIVKKPGNIY
YLYKRESGQQYFSIISPKEWGTSCPHDFLGAYKLQHDLSWTPYEDIEKQDAKISMMDTLL
SQSVALPPCTEPNFQGLTH
Target Bioclass
Other
Function
Regulates clathrin-mediated endocytsois of cargos such as transferrin probably through the association and modulation of adaptor protein complex 2 (AP-2). Has a role in ciliogenesis. Required for proper cephalic and left/right axis development.
Uniprot ID
Q9BV29
Ensemble ID
ENST00000358005.7
HGNC ID
HGNC:28295

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K108(10.00); K89(5.00)  LDD0277  [1]
IA-alkyne
 Probe Info  		C25(12.19); C47(12.19)  LDD1710  [2]
Methacrolein
 Probe Info  		N.A.  LDD0218  [3]
AOyne
 Probe Info  		15.00  LDD0443  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0024  KB05 T cell-activated C25(12.19); C47(12.19)  LDD1710  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock protein HSP 90-alpha (HSP90AA1) Heat shock protein 90 family P07900
tRNA modification GTPase GTPBP3, mitochondrial (GTPBP3) TrmE GTPase family Q969Y2
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protection of telomeres protein 1 (POT1) Telombin family Q9NUX5

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.