Details of the Target

General Information of Target

Target ID LDTP15890
Target Name Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 (CHCHD7)
Gene Name CHCHD7
Gene ID 79145
Synonyms
Coiled-coil-helix-coiled-coil-helix domain-containing protein 7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAANCTSSWSLGESCNRPGLELPRSMASSETQLGNHDVDPEISHVNFRMFSCPKESDPIQ
ALRKLTELCHLWLRPDLHTKEQILDMLVMEQFMISMPQELQVLVMMNGVQSCKDLEDLLR
NNRRPKKWSVVTFHGKEYIVQDSDIEMAEAPSSVRDDLKDVSSQRASSVNQMRPGEGQAH
RELQILPRVPALSRRQGEDFLLHKSIDVTGDPKSLRPKQTLEKDLKENREENPGLTSPEP
QLPKSPTDLVRAKEGKDPPKIASVENVDADTPSACVVEREASTHSGNRGDALNLSSPKRS
KPDASSISQEEPQGEATPVGNRESPGQAGMNSIHSPGPASPVSHPDGQEAKALPPFACDV
CEKRFTCNSKLVIHKRSHTGERLFQCNLCGKRFMQLISLQFHQRTHTGERPYTCDVCQKQ
FTQKSYLKCHKRSHTGEKPFECKDCKKVFTYRGSLKEHQRIHSGEKPYKCSKCPRAFSRL
KLLRRHQKTHPEATSQ
Target Bioclass
Other
Family
CHCHD7 family
Subcellular location
Mitochondrion intermembrane space
Uniprot ID
Q9BUK0
Ensemble ID
ENST00000303759.3
HGNC ID
HGNC:28314

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
FTC133 SNV: p.P65S .
HCT116 SNV: p.L42S .
LNCaP clone FGC SNV: p.E75G .
NCIH2291 SNV: p.Ter86LextTer9 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		N.A.  LDD2223  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264