Details of the Target

General Information of Target

Target ID LDTP15878
Target Name Nicolin-1 (NICN1)
Gene Name NICN1
Gene ID 84276
Synonyms
Nicolin-1; NPCEDRG; Tubulin polyglutamylase complex subunit 5; PGs5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDCRVHMRPIGLTWVLQLTLAWILLEACGGSRPLQARSQQHHGLAADLGKGKLHLAGPCC
PSEMDTTETSGPGNHPERCGVPSPECESFLEHLQRALRSRFRLRLLGVRQAQPLCEELCQ
AWFANCEDDITCGPTWLPLSEKRGCEPSCLTYGQTFADGTDLCRSALGHALPVAAPGARH
CFNISISAVPRPRPGRRGREAPSRRSRSPRTSILDAAGSGSGSGSGSGP
Target Bioclass
Other
Subcellular location
Nucleus
Uniprot ID
Q9BSH3
Ensemble ID
ENST00000273598.8
HGNC ID
HGNC:18317

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MELHO SNV: p.R110K .
REH SNV: p.P154S .
SW1116 SNV: p.R110K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C8(2.18)  LDD3407  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A-172 C8(1.30)  LDD2251  [1]
 LDCM0023  KB03 A-172 C8(1.83)  LDD2668  [1]
 LDCM0024  KB05 RKO C8(2.18)  LDD3407  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840