Details of the Target

General Information of Target

Target ID LDTP15851
Target Name Actin-related protein 2/3 complex subunit 5-like protein (ARPC5L)
Gene Name ARPC5L
Gene ID 81873
Synonyms
Actin-related protein 2/3 complex subunit 5-like protein; Arp2/3 complex 16 kDa subunit 2; ARC16-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEGAALLKIFVVCIWVQQNHPGWTVAGQFQEKKRFTEEVIEYFQKKVSPVHLKILLTSDE
AWKRFVRVAELPREEADALYEALKNLTPYVAIEDKDMQQKEQQFREWFLKEFPQIRWKIQ
ESIERLRVIANEIEKVHRGCVIANVVSGSTGILSVIGVMLAPFTAGLSLSITAAGVGLGI
ASATAGIASSIVENTYTRSAELTASRLTATSTDQLEALRDILRDITPNVLSFALDFDEAT
KMIANDVHTLRRSKATVGRPLIAWRYVPINVVETLRTRGAPTRIVRKVARNLGKATSGVL
VVLDVVNLVQDSLDLHKGAKSESAESLRQWAQELEENLNELTHIHQSLKAG
Target Bioclass
Other
Family
ARPC5 family
Subcellular location
Cytoplasm, cytoskeleton
Function
May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Uniprot ID
Q9BPX5
Ensemble ID
ENST00000259477.6
HGNC ID
HGNC:23366

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K89(5.00)  LDD0277  [1]
Acrolein
 Probe Info  		N.A.  LDD0223  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0223  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Actin-related protein 2/3 complex subunit 4 (ARPC4) ARPC4 family P59998
Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G) GADD45 family O95257

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.